@ARTICLE{M, author = {M, Hashemiasil and P, Nazarali and R, Soori and A, Ramezankhani and M, Namjoo and }, title = {Comparison of carotid artery intima-media thickness (CIMT) and acute serum adropin and nitric oxide response after exercise in athletes and non-athletes}, volume = {9}, number = {2}, abstract ={Background & Aim: Adropin is a peptide hormone that regulates cardiovascular function and plays a protective role in the development of cardiovascular disease. The present study aimed to compare the effect of carotid artery intima-media thickness (CIMT) and acute effect of one-session exercise on serum adropin and nitric oxide (NO) in athlete and non-athlete participants. Methods: This study was carried out in a quasi-experimental design. Twelve health athlete and eleven health non-athlete participants were selected by convenience sampling. At first, a carotid intima-media thickness (CIMT) was measured. Then, Blood samples were collected from participants before and after exercise intervention using a Bruce protocol for evaluation of adropin and nitric oxide. Data were analyzed by paired and independent sample t-test, one-way analysis of covariance and Pearson correlation at significant levels of P≤0.05. Results: There were significant differences in CIMT variable between the athletes and non-athletes and it was higher in the non-athlete participants (P=0.002). After the exercise intervention, adropin levels were significantly increased (P=0.017) in the athletes, However, NO levels increased significantly in both groups (P<0.05). There were also significant differences in serum adropin and NO levels between non-athletes and athletes (P <0.05). A significant positive correlation was observed between changes of adropin and NO (P=0.001, r=0.794). Conclusion: Prolonged exercise training reduced CIMT in athletes. Adropin and NO levels were increased more in athletes than non-athlete subjects after one session of exercise. The long-term adaptations to exercise training leads to a greater increase in vascular biomarkers in athletes than non-athletes after an acute physical activity. }, URL = {http://jms.thums.ac.ir/article-1-951-en.html}, eprint = {http://jms.thums.ac.ir/article-1-951-en.pdf}, journal = {Journal title}, doi = {}, year = {2021} }