Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
Photocatalytic process using magnesium oxide nanoparticles for amoxicillin removal from aqueous solution
1
12
FA
Elham
Norabadi
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran
e.noorabadi17@gmail.com
N
0000-0002-6085-4214
Ferdous
Kord Mostafapour
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran
ferdos_66@yahoo.com
N
0000-0000-0000-0000
Hossein
Kamani
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran
hossein_kamani@yahoo.com
Y
0000-0002-1498-9580
Edris
Bazrafshan
Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
.و..و.
N
0000-0000-0000-0000
Seyed Davoud
Ashrafi
Department of Environmental Health, School of Health, Guilan University of Medical Sciences, Rasht, Iran
ashrafid@gmail.com
N
0000-0000-0000-0000
khadijeh
pirasteh
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran
kadigeh.pirasteh.70@gmail.com
N
0000-0000-0000-0000
Mohadeseh
Dashtizadeh
Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran
mohadesehdashtizadeh@gmail.com
N
0000-0000-0000-0000
Background & Aim: Excessive consumption of antibiotics and their incomplete metabolization in human and animals, as well as inadequate removal by conventional waste water system leads to the release of these chemicals into the environment. Antibiotics have adverse effects including bacterial resistance, digestive disorders and genotoxic. Therefore the aim of this study was to survey amoxicillin removal by photocatalytic process using magnesium oxide nanoparticles.
Methods: This experimental study was carried in the form of batch in the laboratory. In this study, independent parameters including pH (3, 7, 11), magnesium oxide nanoparticles concentration (250, 500, 750 ml/L) and reaction time (30, 60, 90) were evaluated for getting high mineralization efficiency. In order to achieve the optimal experimental conditions, response surface methodology (RSM) model was designed and applied. Analysis of variance (ANOVA) was used for data analysis.
Results: According to the obtained results, the effect of independent parameters including pH and nanoparticles on removal process was significant (p-value<0.05) and the highest efficiency for mineralization of amoxicillin was achieved 79.0% in optimum condition pH: 11, nanoparticle concentration: 500 mg/L and reaction time: 90 min.
Conclusion: Photocatalytic process using magnesium oxide can be considered as an effective method for amoxicillin removal from aqueous solution.
Amoxicillin, photocatalytic process, nanoparticles, magnesium oxide
http://jms.thums.ac.ir/article-1-554-en.html
http://jms.thums.ac.ir/article-1-554-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
Cloning, expression, purification and the study of immunotherapy status of TGFαL3-SEB chimeric protein in breast cancer treatment
13
25
FA
Forough
Yousefi
Department of Microbiology and Parasitology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
forough.y@gmail.com
N
Seyed Davar
Siadat
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
d.siadat@gmail.com
N
Mohammad Mehdi
Aslani
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
mmaslani@yahoo.com
N
Abbas Ali
Imani-Fooladi
Applied Microbiology Research center, Baqiyatallah University of Medical Sciences, Tehran, Iran
imanifouladi.a@gmail.com
N
Omid
Nasiri
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
omid201262@gmail.com
N
Seyed Fazlollah
Mousavi
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
sadatff@yahoo.com
Y
Background & Aim: Bacterial superantigens, stimulate polyclonal T cells irrespective of their antigen specificity, resulting in a massive release of cytokines from T cells and monocytes, and suggest that that they could be candidates of new antitumor agents. Recent attempts have been done to specifically target superantigens towards tumors. Here, we evaluate TGFαL3-SEB fusion protein as a new antitumor candidate by genetically fusing the third loop of transforming growth factor alpha (TGFalphaL3) to staphylococcal enterotoxin type B.
Methods: Recombinant TGFαL3-SEB sequence was constructed by fusing the N-terminal of tgfαl3 and C-terminal of seb using hydrophobic GGSGSGGG amino acid linker. In this study, gene coding for the SEB superantigen was amplified. The PCR product containing the seb gene was digested by EcoRI and HindIII and cloned in pET28a expression vector. Then the synthetic tgfα-linker sequence was digested by BamHI and EcoRI and cloned in pET28::seb vector. The recombinant pET28:tgfαl3-seb transformed into E. coli BL21(DE3). Expression of recombinant protein was examined by SDS-PAGE and western blotting. In vitro antitumor activity against MDA-MB-468, human breast cancer cells expressing EGFR, was evaluated.
Results: Cloning of tgfαl3-seb was confirmed by colony-PCR, enzymatic digestion and sequencing. The recombinant TGFαL3-SEB fusion protein with molecular weights of 31kDa was expressed and confirmed by anti-his western-blot analysis. The TGFaL3-SEB chimeric protein exhibited potent in vitro antitumor activity.
Conclusion: Our findings indicated that TGFαL3-SEB fusion protein can be successfully constructed expressed and purified and may serve as a useful antitumor candidate for breast cancer immunotherapy.
SEB, Staphylococcus aureus, Cloning, Immunotherapy, Transforming Growth Factor alpha, Breast Neoplasms
http://jms.thums.ac.ir/article-1-528-en.html
http://jms.thums.ac.ir/article-1-528-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
Comparison of the effect of combined physical training (endurance, strength) with and without flaxseed on the levels of estrogen, lipid and body composition of inactive menopausal women
26
36
FA
Nasrin
Jahanshiri
Department of Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Iran
jahanshiri.nasrin@yahoo.com
N
Nahid
Bijeh
Department of Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Iran
bijeh@um.ac.ir
Y
Background & Aim: Increase in cardiovascular disease risk factors in postmenopausal women is because of adverse changes in plasma lipoproteins due to the lack of estrogen. The aim of this study was to investigate the effect of eight weeks of combined training with and without flaxseed consumption on estrogen, lipid level and body composition in sedentary postmenopausal women.
Methods: In this semi-experimental study, 30 sedentary postmenopausal women within the age range of 50 to 60 years old were selected as volunteers and were divided into two groups: Combined training (n=15) and combined training + flaxseed (n=15). The exercise protocol included 8 weeks of aerobic training with the intensity of 60% to 80% of the maximal heart rate and the resistance training with the intensity of 60% to 80% of one-repetition maximum. The second group, in addition to physical training, consumed 25 grams of flaxseed. Data were analyzed by paired-samples t-test and independent-samples t-test at a significance level of p<0.05.
Results: In the combined training group, estrogen and high-density lipoprotein levels were significantly increased, whereas the BMI and triglyceride were decreased (p>0.05). In the combined exercise group with flaxseed consumption, estrogen, and high-density lipoprotein were increased significantly, whereas the BMI and triglyceride (p=0.015) were decreased (p>0.05).
Conclusion: Collectively, combining exercise with and without flaxseed can reduce the complications of menopause by improving the lipid and estrogen levels as well as body composition. It can act as an effective strategy to increase cardiovascular endurance by maximizing the amount of oxygen consumed.
Combined training, Estrogen, Lipid level, Postmenopausal women, Flaxseed
http://jms.thums.ac.ir/article-1-547-en.html
http://jms.thums.ac.ir/article-1-547-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
The Effect of Methimazole-Induced Hypothyroidism on fertility in female Rats
37
47
FA
hamidreza
Adeli Bhroz
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
hamidrezaadeli82@gmail.com@gmail.com
N
Kazem
parivar
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
parivar@yahoo.com
Y
Iraj
Amiri
Anatomy and Embryology Department, Medical School, Hamadan University of Medical Science, Hamadan, Iran
amiri@yahoo.com
N
Nasim
Hayati Roodbari
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
hayati@yahoo.com
N
Background & Aim: Thyroid hormones play critical roles in regulating body metabolism, reproduction, fertility, and the continuation of fertility and delivery. Therefore, this study was designed to investigate the effects of thyroid hormones on fertility rate, duration of pregnancy, childbirth success rate, number of neonates and weight of one-day old female mice.
Methods: 30 adult female mice were selected with the mean weight of 28 g and divided into three groups: Control group, pure water, low dose group, receiving 20 mg/100 ml, and high dose group receiving 100 mg/100 ml of Methimazole powder dissolved in water until the end of pregnancy. In each group, the duration of pregnancy, the number of successful delivery and the weight of newborns were evaluated on the first day of birth. Also, after the end of pregnancy, the mice were sacrificed, then blood samples were taken and the serum levels of thyroid hormones level were measured. In this study, SPSS software version 22 and one way ANOVA were used to analyze the data.
Results: The rate of successful delivery among different groups were as follows: 9/10 in control group, 8/10 in low dose group and 4/10 in high does group in which the reduction rate was statistically significant compared to the control group (P = 0.032) .The pregnancy period in both experimental groups did not show a significant increase compared to the control group, the number of newborns in each successful delivery showed a significant decrease compared to the control group in both experimental groups (low dose 0.039, high dose 0.042).
Conclusion: The study suggests that reducing thyroid hormone after insemination can also affect embryo-fetal development, reducing births and increasing abortions.
Hypothyroidism, Methimazole, Fertility,Mature Mice
http://jms.thums.ac.ir/article-1-538-en.html
http://jms.thums.ac.ir/article-1-538-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
Diagnosis of Coronary Artery Disease using Neuro-fuzzy-based Method
48
59
FA
Iman
Zabbah
Department of computer Engineering, Tehran North Branch,Islamic Azad University, Tehran,Iran
imanzabbah@gmail.com
N
Zahra
Koohjani
Department of Medical Informatics, School of Management and Medical Informatics, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
zahrakoohjani1@gmail.com
N
Ali
Maroosi
Department of Computer Engineering , university of Torbat Heydarieh,Torbat Heydarieh, Iran
ali.maroosi@gmail.com
N
Kamran
Layeghi
Department of computer Engineering, Tehran North Branch,Islamic Azad University, Tehran,Iran
kamilaayeghiye@gmail.com
Y
Background & Aim: Coronary artery disease is one of the most common diseases in different societies. Coronary angiography is established as one of the best methods for diagnosis of this disease. Angiography is an invasive and costly method. Furthermore, it is associated with risks such as death, heart attack, and stroke. Thus, this study introduces a neuro-fuzzy-based method which can help the physicians in prediction of patient’s coronary artery condition.
Methods: This is an analytical study carried on 200 patients of Cardiovascular Center in Torbat Heydarieh. Patient records include 13 risk factors and are non-attributable. In this work, models are presented based on data mining methods for the diagnosis of coronary artery disease Furthermore, artificial neural network and neuro-fuzzy method were used for modeling the diagnosis of coronary artery disease.
Results: The mean square error (MSE) of prediction for artificial neural network and neuro-fuzzy method were p=0.2574 and p=0.0007, respectively.
Conclusion: Since angiography is invasive and associated with various risks, we suggest the use of non-invasive methods with low error and high reliability. New data mining strategies can be effective in reducing the mentioned complications.
Coronary artery disease, Artificial neural network, Neuro-fuzzy method
http://jms.thums.ac.ir/article-1-564-en.html
http://jms.thums.ac.ir/article-1-564-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
Factors affecting preconception care in married women participating in premarital educational courses: Application of planned behavior theory
60
70
FA
Ozra
Ghafoori
Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
o.ghafoori@qums.ac.ir
N
0000-0001-6594-4588
Amir
Pakpour
Department of Health Education and Promotion, School of Health, Social Determinants of Health Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
apakpour@qums.ac.ir
N
0000-0002-8798-5345
Zinat
Jourabchi
Department of Maternal and child & Midwifery, Faculty of Nursing and Midwifery, Qazvin University of Medical and Health Sciences, Qazvin, Iran
zjourabchi@qums.ac.ir
Y
0000-0003-0422-0193
Background & Aim: To reduce the complications of pregnancy and childbirth, it is necessary to identify the most effective way to provide integrated services. Therefore, the present study was conducted to evaluate the factors affecting the delivery of prenatal care using the theory of planned behavior.
Methods: This descriptive - analytic cross - sectional study was conducted in 2018-2019. The study population included women who participated in pre-marriage training classes, of which 150 were randomly selected. For the tool, a questionnaire was developed in the framework of planning behavior theory. Descriptive statistics, linear regression and univariate analysis of variance were performed using SPSS software version 22.
Results: The mean age of participants was 24.67 ± 5.96 years. The mean score for attitude was 41.01 ± 5.88, the mean score for subjective norms 25.53 ± 4.92, mean score for perceived behavioral control 24.77 ± 4.94, and mean score The behavioral intention of individuals was 32.06 ± 5.85. In the first stage, attitude was the most predictive of behavioral intention, and in the second stage, the combination of perceived behavioral control with an attitude of intention to do behavior increased by 12% (p = 0.0001).
Conclusion: Women have a positive attitude towards the importance of preconception care, but their perceived behavioral control is low. Strengthening perceived behavioral control increases behavioral intent. Moreover, training men in this area will increase the positive mental norms.
Preconception care, Theory of Planned Behavior, subjective norms
http://jms.thums.ac.ir/article-1-548-en.html
http://jms.thums.ac.ir/article-1-548-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
Investigating Anthropometric Indices of Termed Newborns in Torbat Heydarieh as compared to the global Standards within 2017-2018
71
80
FA
Akram
Ashrafizaveh
Department of Midwifery, school of nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
ashrafia1@thums.ac.ir
N
Eham
Azmoude
Department of Midwifery, school of nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Azmoudehe@thums.ac.ir
Y
Maryam
Tatari
Tehran University of Medical Sciences, Tehran, Iran
N
Hossien
Azmoude
Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
azmoudehe@gmail.com
N
Mahtab
Senobari
Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
senobari7421.m@gmail.com
N
Maryam
KHakbaz
Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
N
Background & Aim: The study of anthropometric measurements at birth leads to the identification of neonates with abnormal intrauterine growths and provides desirable care for the neonates who are at risk of postpartum complications. This study aimed to determine the anthropometric measurements among full term neonates in Torbat Heydariyeh city compared to the global standards reported by the World Health Organization and the Center for Disease Control within 2017-2018.
Methods: In this cross sectional study, a number of 200 healthy full term born in the 9-Day Teaching Hospital of Torbat Heydariyeh were evaluated. Maternal fundal height and abdominal circumference before birth and neonates' anthropometric parameters such as birth weights, crown-heel length, head and chest circumferences were taken within 24 hours of birth using standard techniques. Data analysis was performed using Statistical Package for Social Sciences version 16.0 .
Results: Based on the findings, the female birth weight mean was lower than the average of WHO and CDC. In males, the mean weight was significantly less than the 50th CDC percentile (p=0.001). Inconsistently, the average height of male and femaleneonates were significantly higher than the WHO and CDC values (P<0.05). The males and females head circumference mean did not differ from the WHO values (p>0.05), but it was significantly less than CDC values (p=0.001). There was a positive correlation between all anthropometric measurements with gestational age, fundal height and maternal abdominal circumference (p <0.05). The mean distance from the previous birth was inversely related to the height (p=0.021) and head circumference (p=0.037) of the neonates.
Conclusion: The males and females birth weight and head circumference mean was lower from the values reported by CDC and the female birth weight mean and the males and females head circumference mean was lower from the values reported by WHO. Further studies are suggested to be performed in other regions of the country to assess other probable factors associated with these indicators.
Anthropometry, Gestational age, Fundal height, Newborn, Iran
http://jms.thums.ac.ir/article-1-506-en.html
http://jms.thums.ac.ir/article-1-506-en.pdf
Torbat Heydarieh University of Medical Sciences
Journal of Torbat Heydariyeh University of Medical Sciences
2716-9669
2716-9669
6
3
2018
12
1
The trend of population aging and planning of health services for the elderly: A review study
81
95
FA
Abdolvahed
Khodamoradi
Department of Health Economics, Social Security Research Institute, Tehran, Iran
ahmadibatool.2016@gmail.com
N
Soheil
Hassanipour
Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
N
Reza
Daryabeigi Khotbesara
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Science, Deakin University, Melbourne, Australia
Y
Batol
Ahmadi
Department of health management and economics, School of public health, Tehran University of Medical Sciences, Tehran, Iran
N
Background & Aim: Ageing represents the accumulation of changes in a human being over time, and it is synonymous with the beginning of the age of 65.The purpose of this paper is to provide a picture of the growth of the elderly population in the world and planning and policies to provide health services to this category of the population.
Methods: This study was conducted to review. There were comprehensive review of studies of various aspects of the aging population and their health problems and planning for their health care with use of key words "Elderly population", "elderly health", "elderly health plan" on Institute of Information Science, the journal database and Medline database was conducted. In the next step, screening was conducted with regard to inclusion and exclusion criteria, in three phases (according to the title, abstract and original paper) and data extraction on the remaining articles (15 articles) was performed. Finally was used a meta-analysis or fictional (quote) with respect to homogeneous or heterogeneous of data.
Elderly, Health services, Iran
http://jms.thums.ac.ir/article-1-544-en.html
http://jms.thums.ac.ir/article-1-544-en.pdf