Angioedema is a rare disease with autosomal dominant is largely complement system. This disease is characterized by non-itchy mucocutaneous and non-pitting edema. In some cases, this disease appears as a result of Captopril intake which is orally and sublingually used in the treatment of severe hypertension.

In this study, angioedema as a rare complication of Captopril sublingual intake was investigated in a 49-years-old patient. In several hours after taking Captopril, patient showed the Angioedema signs. Due to severe edema of tongue, lips and larynx, quick tracheostomy was performed and patient was hospitalized in intensive care unit. Having started the treatment measures and hospitalization, the patient discharged with good general condition.