Volume 5, Issue 4 (3-2018)                   2018, 5(4): 60-71 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

GHolami M, Sadegh M. Assessing the effect of drug tolerance due to chronic administration of morphine and salicylate on synaptic plasticity. Journal title 2018; 5 (4) :60-71
URL: http://jms.thums.ac.ir/article-1-471-en.html
1- Neurosciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
2- Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Abstract:   (5931 Views)
Background & Aim: Salicylates and opioids are widely used in chronic pain relief. Chronic use of these drugs reorganizes synaptic function, especially experience-dependent plasticity in brain regions. Therefore, in this study the effects of chronic administration of salicylate and morphine on synaptic plasticity were investigated.
Methods: in this review, Elsevier, Science Direct, PubMed and Google Scholar databases were searched for the following keywords: salicylate, morphine, drug tolerance, and synaptic plasticity. At the end, 62 of the obtained reports were included in the study.
Results: In addition to induction of tolerance to anti-nociceptive effect and cross-tolerance, chronic salicylate administration as like as morphine has long-lasting effects on hippocampal neuronal networks which are manifested as excitability of neurons and ability of activity and experience-dependent plasticity. Some of these effects can be documented in the hippocampus-related functions such as spatial learning and memory.
Conclusion: Considering the effects of salicylate and morphine on the nervous system and synaptic transmission, the effects of these drugs on the processing of input data and as a result on cognitive functioning would not be unlikely, thus necessitating further behavioral and electrophysiological studies.
 
Full-Text [PDF 16 kb]   (2232 Downloads)    
Type of Study: Applicable | Subject: Special
Received: 2018/01/13 | Accepted: 2018/04/12 | Published: 2018/04/12

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Designed & Developed by : Yektaweb