TY - JOUR T1 - Preparation and in-vitro evaluation of an in-situ gel forming of chitosan-based morphine formulation as an intranasaladministrationRunning title: An intranasal in-situ gel forming of morphine TT - تهیه و ارزیابی برونتنی فرمولاسیون ژلشونده برپایه پلیمرکیتوزان و حاوی مرفین به عنوان یک سامانه دارورسانی از مسیر بینی JF - thums-jms JO - thums-jms VL - 9 IS - 3 UR - http://jms.thums.ac.ir/article-1-1018-en.html Y1 - 2022 SP - 1 EP - 12 KW - Sol-Gel- chitosan KW - Morphine KW - Nasal drag delivery N2 - Background & Aim: Intranasal delivery through the epithelium of nose is an interesting and useful idea because it has a fast onset of effect with any metabolism in liver and digestive system, also it is user-friendly, noninvasive and without pain. In this study, we aimed to prepare and evaluate an in-situ gel forming of chitosan-based morphine formulation as an intranasal administration in vitro. Methods: In this project, the in-situ gel forming of morphine-loaded chitosan formulation was firstly prepared and finally its physicochemical properties was determined in order to achieve the technology of a gel-forming formulation for morphine nasal delivery. Results: The final prepared formulation was in the form of sol in room temperature; while, it was transmitted to the gel form at 37 °C and subsequently returned to the sol form after decreasing temperature. The obtained results of burst release test showed a sustained release of morphine from the polymeric matrix of chitosan. Additionally, the formulation showed that it could be sprayed in nostril with no toxicity. Conclusion: The biodegradable and biocompatible intranasal form of morphine could be gelled in the shortest possible time before leaving the nose at a temperature of 34 °C. Also, based on the release pattern of morphine, morphine could slowly induce its analgesic effects. M3 ER -