Journal of Torbat Heydariyeh University of Medical Sciences
مجله دانشگاه علوم پزشکی تربت حیدریه
jmsthums
Medical Sciences
http://jms.thums.ac.ir
1
admin
2716-9669
2716-9669
10.61882/jmsthums
fa
jalali
1401
12
1
gregorian
2023
3
1
10
4
online
1
fulltext
fa
بررسی ارتباط بین سطح اسیداوریک سرم باشدت علایم بالینی دربیماران آرتریت روماتویید
Investigating the relationship of serum uric acid level and clinical symptoms in rheumatoid arthritis patients
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">زمینه و هدف</span></span></b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">: آرتریت روماتوئید یک بیماری اتوایمیون و</span></span> <span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">مزمن است که با یک پلی آرتریت التهابی مشخص میشود و ترجیحاً مفاصل کوچک را تحت تأثیر قرار می دهد. برخی عوامل از جمله سن بالا، فشارخون سیستولیک و میزان </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">LDL</span></span><span style="font-family:"B Nazanin""><span style="color:black"> ، </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">ESR</span></span><span style="font-family:"B Nazanin""><span style="color:black"> ،</span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">GFR</span></span><span style="font-family:"B Nazanin""><span style="color:black"> در بروز بیماری</span></span><span dir="LTR" lang="AR-SA" style="font-family:"Times New Roman",serif"><span style="color:black">‎</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">های قلبی عروقی در این بیماران موثر می باشد. مطالعهی حاضر با هدف تعیین ارتباط بین سطح اسیداوریک سرم با شدت علایم بالینی بیماری در بیماران آرتریت روماتوئید انجام شد</span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">.</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">روشها</span></span></b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">: در این مطالعه توصیفی- تحلیلی داده های مورد نیاز از تمامی پرونده های بیماران مراجعه کننده به کلینیک­های روماتولوژی تابعه دانشگاه علوم پزشکی بیرجند در سال 1399 جمع آوری گردید. متغیرهای مورد بررسی شامل سن، میزان </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">ESR</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black"> ، </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">CRP</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">، </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">RF</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">، </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">Anti ccp</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">، سطح اسیداوریک سرم و میزان </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">DAS28</span></span><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black"> بیماران بود. دادهها با کمک نرمافزار </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black">SPSS</span></span><span style="font-family:"B Nazanin""><span style="color:black"> نسخه 22 و آزمونهای آماری من و تینی، کراسکال والیس و ضریب همبستگی اسپیرمن تحلیل گردید. میزان خطا کمتر از 0/05 بود. </span></span><span dir="LTR" style="font-family:"Times New Roman",serif"><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">نتایج</span></span></b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">: در این مطالعه اکثریت افراد مورد مطالعه (74/4%) خانم و ما بقی آقا بودند. میانگین سن بیماران 14/36±47/25 بود. میانگین سطح اسیداوریک سرم بیماران 1/46 ±6/286 بود. برطبق نتایج ، بین سطح اسیداوریک سرم باشدت علایم بالینی بیماران رابطه ­ی معناداری وجود داشت (p=0/001 x<sup>2</sup>=17/271 ) </span></span><span class="fontstyle01" style="font-family:"B Lotus""><span style="color:black"><span style="font-weight:normal"><span style="font-style:normal"><b><span lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span style="font-family:"B Nazanin""></span></span></span></b></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">نتیجهگیری</span></span></b><span lang="AR-SA" style="font-family:"B Nazanin""><span style="color:black">: با توجه به ارتباط بین سطح اسیداوریک سرم با شدت علایم بالینی در بیماران مبتلا به آرتریت روماتوئید، به نظر می رسد می توان از این شاخص به عنوان یک نشانگر تعیین شدت علایم بالینی بیماری در این مبتلایان استفاده نمود. </span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">Background and aim</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">: </span></span></span></span><span lang="EN" style="font-family:"Times New Roman",serif">Rheumatoid arthritis is a chronic autoimmune disease characterized by an inflammatory polyarthritis that preferentially affects small joints.</span> <span lang="EN" style="font-family:"Times New Roman",serif">Some factors such as old age, systolic blood pressure and LDL, ESR, GFR are effective in the occurrence of cardiovascular diseases in these patients.</span> <span lang="EN" style="font-family:"Times New Roman",serif">The present study was conducted with the aim of determining the relationship between serum uric acid level and severity of clinical symptoms in rheumatoid arthritis patients.</span><span dir="RTL" style="font-family:"Times New Roman",serif" lang="FA"></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">Methods</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">:</span></span></span></span> <span lang="EN" style="font-family:"Times New Roman",serif">In this descriptive-analytical study, the required data were collected from all the files of patients referred to rheumatology clinics of Birjand University of Medical Sciences in 2019.</span> <span lang="EN" style="font-family:"Times New Roman",serif">The investigated variables included age, ESR, CRP, RF, Anti ccp, serum uric acid level and DAS28 level of the patients.</span> <span lang="EN" style="font-family:"Times New Roman",serif">Data were analyzed with the help of SPSS version 22 software and statistical tests of Mann and Tiny, Kraskal-Wallis and Spearman's correlation coefficient.</span> <span lang="EN" style="font-family:"Times New Roman",serif">The error rate was less than 0.05.</span><span dir="RTL" style="font-family:"Times New Roman",serif" lang="FA"></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">Results</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">: </span></span></span></span><span lang="EN" style="font-family:"Times New Roman",serif">In this study, the majority of subjects (74.4%) were women and the rest were men.</span> <span lang="EN" style="font-family:"Times New Roman",serif">The average age of the patients was 47.25±14.36.</span> <span lang="EN" style="font-family:"Times New Roman",serif">The mean serum uric acid level of the patients was 6.286±1.46.</span> <span lang="EN" style="font-family:"Times New Roman",serif">According to the results, there was a significant relationship between the serum uric acid level and the clinical symptoms of the patients (P=0.001, X2=17.271).</span><span dir="RTL" style="font-family:"Times New Roman",serif" lang="FA"></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">Conclusion</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"><span style="color:black">: </span></span></span></span><span lang="EN" style="font-family:"Times New Roman",serif">Considering the relationship between serum uric acid level and severity of clinical symptoms in patients with rheumatoid arthritis, it seems that this index can be used as an indicator to determine the severity of clinical symptoms in these patients.</span><span dir="RTL" style="font-family:"Times New Roman",serif" lang="FA"></span></span></span></span></span><br>
آرتریت روماتویید-اسیداوریک سرم-DAS28
Rheumatoid arthritis-serum uric acid-DAS28
24
30
http://jms.thums.ac.ir/browse.php?a_code=A-10-1282-1&slc_lang=fa&sid=1
Naderi
N
ناهید
نادری
khorashadi.h@gmail.com
100319475328460012791
100319475328460012791
No
Birjand University of Medical Sciences
دانشگاه علوم پزشکی بیرجند
Heydari
SH
شیما
حیدری
shima.heydari_b83@yahoo.com
100319475328460012792
100319475328460012792
Yes
Birjand University of Medical Sciences
دانشگاه ﻋﻠﻮم پزشکی ﺑﯿﺮﺟﻨﺪ
Atabati
E
الهام
عتباتی
elham1405@yahoo.com
100319475328460012793
100319475328460012793
No
Mashhad University of Medical Sciences
دانشگاه علوم پزشکی مشهد
Ramezani
A
عباسعلی
رمضانی
ramazani_ab@bums.ac.ir
100319475328460012794
100319475328460012794
No
Birjand University of Medical Sciences
دانشگاه علوم پزشکی بیرجند