Volume 2, Issue 4 (1-2015)                   2015, 2(4): 45-38 | Back to browse issues page

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lashkarizadeh D M R, Bazrafshan M R, Izadi A, HOSEINI F. Evaluation of HER2/neu gene amplification frequency in patients with gastric cancer using MLPA method . Journal of Torbat Heydariyeh University of Medical Sciences. 2015; 2 (4) :45-38
URL: http://jms.thums.ac.ir/article-1-264-en.html
1- Genetic PhD
2- surgeon
Abstract:   (1826 Views)

Background and aims:  Gastric malignancies have the fourth place among the most prevalent cancers. In many cancers, overexpressing of HER2/neu gene has been observed with a poor prediction. Up to now, there is a little information about the duplication of HER2/neu gene in gastric cancer using MLPA method. The present study aimed to investigate the frequency of mutations resulting from amplification of HER2/neu gene using MLPA technique in the patients with gastric cancer.

Methods: This is a descriptive study which carried out on 60 samples of tissue block obtained from gastric cancer patients with endoscopic and surgical history between 1376-1391 years in Afzalipoor health centers to investigate the deletion and insertion mutations in HER2/neu.

Results: The study population consisted of 73.3% females and 26.7% males with the mean age of 62.71. Overall, the frequency of the amplification of HER2/neu gene in the low and high levels was 10% and 3.3%, respectively.

Conclusion: It seems that, the amplification frequency of HER2/neu gene in men is more than women. However, it is recommended to conduct further studies.

Full-Text [PDF 271 kb]   (478 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/01/20 | Accepted: 2016/03/5 | Published: 2016/04/27

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