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jmsthums 2026, 14(1): 14-21 |
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Nojavan R, Rahmani S A, Ghasemzadeh A. Prevalence of chromosomal abnormalities in infertile men with non-obstructive azoospermia and severe oligospermia in the northwest of Iran. jmsthums 2026; 14 (1) :14-21
URL: http://jms.thums.ac.ir/article-1-1444-en.html
URL: http://jms.thums.ac.ir/article-1-1444-en.html
1- Department of Biology, College of Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2- Department of Medical Genetics, College of Medical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3- Department of Obstetrics and Gynecology, College of Medical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2- Department of Medical Genetics, College of Medical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
3- Department of Obstetrics and Gynecology, College of Medical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract: (15 Views)
Background & Aim: Approximately 4% of men worldwide suffer from infertility, with a significant number of them suffering from non-obstructive azoospermia or severe oligospermia. One of the most important causes of these conditions is chromosomal abnormalities. Despite numerous studies worldwide, there is limited regional data available for the northwest Iran. Therefore, the present study aimed to investigate various numerical and structural abnormalities in order to clarify the role of cytogenetic disorders in the mentioned region.
Methods: In this study, 60 men with non-obstructive azoospermia or severe oligospermia who were referred to a genetic laboratory in Tabriz during 1402-1403. Chromosome analysis was conducted using the standard G-banding method, with at least 25 cells examined for each sample. The results were then analyzed using SPSS version 25 software.
Results: Overall, out of 60 affected individuals, 11 (18.33%) had various types of numerical and structural chromosome abnormalities or chromosomal polymorphisms as determined by cytogenetic testing. Among these abnormalities, Klinefelter syndrome, a type of numerical abnormality of the sex chromosomes, was the most frequently reported. Other abnormalities such as, chromosomal polymorphisms, Robertson translocation, and sex reversal were also reported but at lower frequencies.
Conclusion: The results of this study showed that the prevalence of chromosomal abnormalities in men with non-obstructive azoospermia and severe oligospermia in the northwest region of Iran was relatively high, so that in some cases its percentage was even higher than the reported global average. In fact, the results obtained confirm the role of cytogenetic abnormalities in the development of non-obstructive azoospermia and severe oligospermia phenotypes in the northwest of Iran. These findings indicate the need for cytogenetic studies in the diagnosis and the treatment of infertile men.
Methods: In this study, 60 men with non-obstructive azoospermia or severe oligospermia who were referred to a genetic laboratory in Tabriz during 1402-1403. Chromosome analysis was conducted using the standard G-banding method, with at least 25 cells examined for each sample. The results were then analyzed using SPSS version 25 software.
Results: Overall, out of 60 affected individuals, 11 (18.33%) had various types of numerical and structural chromosome abnormalities or chromosomal polymorphisms as determined by cytogenetic testing. Among these abnormalities, Klinefelter syndrome, a type of numerical abnormality of the sex chromosomes, was the most frequently reported. Other abnormalities such as, chromosomal polymorphisms, Robertson translocation, and sex reversal were also reported but at lower frequencies.
Conclusion: The results of this study showed that the prevalence of chromosomal abnormalities in men with non-obstructive azoospermia and severe oligospermia in the northwest region of Iran was relatively high, so that in some cases its percentage was even higher than the reported global average. In fact, the results obtained confirm the role of cytogenetic abnormalities in the development of non-obstructive azoospermia and severe oligospermia phenotypes in the northwest of Iran. These findings indicate the need for cytogenetic studies in the diagnosis and the treatment of infertile men.
Keywords: Male infertility, Chromosomal abnormality, Karyotype, Klinefelter Syndrome, Chromosomal polymorphism
Type of Study: Applicable |
Subject:
Special
Received: 2025/05/13 | Accepted: 2025/08/27 | Published: 2026/06/29
Received: 2025/05/13 | Accepted: 2025/08/27 | Published: 2026/06/29
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