Volume 9, Issue 3 (1-2022)
jmsthums 2022, 9(3): 1-12 |
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J M, H K, M T, M K. Preparation and in-vitro evaluation of an in-situ gel forming of chitosan-based morphine formulation as an intranasaladministrationRunning title: An intranasal in-situ gel forming of morphine. jmsthums 2022; 9 (3) :1-12
URL: http://jms.thums.ac.ir/article-1-1018-en.html
URL: http://jms.thums.ac.ir/article-1-1018-en.html
1- Department of Nanomedicine, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
2- Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3- School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3- School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (2520 Views)
Background & Aim: Intranasal delivery through the epithelium of nose is an interesting and useful idea because it has a fast onset of effect with any metabolism in liver and digestive system, also it is user-friendly, noninvasive and without pain. In this study, we aimed to prepare and evaluate an in-situ gel forming of chitosan-based morphine formulation as an intranasal administration in vitro.
Methods: In this project, the in-situ gel forming of morphine-loaded chitosan formulation was firstly prepared and finally its physicochemical properties was determined in order to achieve the technology of a gel-forming formulation for morphine nasal delivery.
Results: The final prepared formulation was in the form of sol in room temperature; while, it was transmitted to the gel form at 37 °C and subsequently returned to the sol form after decreasing temperature. The obtained results of burst release test showed a sustained release of morphine from the polymeric matrix of chitosan. Additionally, the formulation showed that it could be sprayed in nostril with no toxicity.
Conclusion: The biodegradable and biocompatible intranasal form of morphine could be gelled in the shortest possible time before leaving the nose at a temperature of 34 °C. Also, based on the release pattern of morphine, morphine could slowly induce its analgesic effects.
Methods: In this project, the in-situ gel forming of morphine-loaded chitosan formulation was firstly prepared and finally its physicochemical properties was determined in order to achieve the technology of a gel-forming formulation for morphine nasal delivery.
Results: The final prepared formulation was in the form of sol in room temperature; while, it was transmitted to the gel form at 37 °C and subsequently returned to the sol form after decreasing temperature. The obtained results of burst release test showed a sustained release of morphine from the polymeric matrix of chitosan. Additionally, the formulation showed that it could be sprayed in nostril with no toxicity.
Conclusion: The biodegradable and biocompatible intranasal form of morphine could be gelled in the shortest possible time before leaving the nose at a temperature of 34 °C. Also, based on the release pattern of morphine, morphine could slowly induce its analgesic effects.
Type of Study: Research |
Subject:
Special
Received: 2021/11/27 | Accepted: 2021/12/27 | Published: 2022/02/5
Received: 2021/11/27 | Accepted: 2021/12/27 | Published: 2022/02/5
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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