Volume 10, Issue 1 (7-2022)
jmsthums 2022, 10(1): 14-27 |
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M P, K Z, A S, A B. Effect of High-Intensity Interval Training (HIIT) on Hypoxia-Inducible Factor-1 Alpha (HIF-1α) Gene Expression in Heart Tissue and Insulin Resistance Index in Type 2 Diabetic Rats. jmsthums 2022; 10 (1) :14-27
URL: http://jms.thums.ac.ir/article-1-1065-en.html
URL: http://jms.thums.ac.ir/article-1-1065-en.html
1- Arak University, Arak, Iran
Abstract: (2597 Views)
Background and Aim: One of the most common metabolic diseases is diabetes with hyperglycemic properties and endogenous insulin dysfunction. This study aimed to evaluate the effect of 10 weeks HIIT on HIF-1α gene expression in heart tissue of rats with type 2 diabetes.
Methods: In this experimental study, 36 Wister rats with a mean weight of 200±58g were randomly assigned to control, diabetic, and diabetic training groups. The diabetic training group received HIIT 10 weeks after induction of diabetes. Twenty-four hours after the last training session, blood serum samples and heart tissue were collected for analysis. Data were analyzed using a one-way analysis of variance and Tukey post hoc test at a significance level of 0.05%.
Results: The results of the present study showed that type 2 diabetes significantly reduces the expression of the HIF-1α gene in the heart tissue of mice with type 2 diabetes (P=0.001). However, HIIT significantly increased the expression of the HIF-1α gene in the diabetic group with exercise compared to the diabetic control group (P = 0.001). The results also showed that HIIT training significantly reduced the insulin resistance index in the diabetic group with exercise compared to the diabetic control group (P = 0.001). At 10 weeks, HIIT had no significant effect on the left ventricular weight of heart tissue (P> 0.05).
Conclusion: In general, based on our findings, diabetes appears to significantly reduce the expression of the HIF-1α gene in heart tissue and HIIT may increase insulin sensitivity and protect HIF-1α from their heart tissue.
Methods: In this experimental study, 36 Wister rats with a mean weight of 200±58g were randomly assigned to control, diabetic, and diabetic training groups. The diabetic training group received HIIT 10 weeks after induction of diabetes. Twenty-four hours after the last training session, blood serum samples and heart tissue were collected for analysis. Data were analyzed using a one-way analysis of variance and Tukey post hoc test at a significance level of 0.05%.
Results: The results of the present study showed that type 2 diabetes significantly reduces the expression of the HIF-1α gene in the heart tissue of mice with type 2 diabetes (P=0.001). However, HIIT significantly increased the expression of the HIF-1α gene in the diabetic group with exercise compared to the diabetic control group (P = 0.001). The results also showed that HIIT training significantly reduced the insulin resistance index in the diabetic group with exercise compared to the diabetic control group (P = 0.001). At 10 weeks, HIIT had no significant effect on the left ventricular weight of heart tissue (P> 0.05).
Conclusion: In general, based on our findings, diabetes appears to significantly reduce the expression of the HIF-1α gene in heart tissue and HIIT may increase insulin sensitivity and protect HIF-1α from their heart tissue.
Type of Study: Research |
Subject:
Special
Received: 2022/05/5 | Accepted: 2022/08/2 | Published: 2022/08/3
Received: 2022/05/5 | Accepted: 2022/08/2 | Published: 2022/08/3
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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