Volume 12, Issue 3 (12-2024)
jmsthums 2024, 12(3): 93-114 |
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A T, M M, O Z. The effect of exercise training on adropin, adiponillin, and insulin resistance indices in overweight and obese adult women: A Systematic Review and Meta-Analysis. jmsthums 2024; 12 (3) :93-114
URL: http://jms.thums.ac.ir/article-1-1334-en.html
URL: http://jms.thums.ac.ir/article-1-1334-en.html
1- Shahid Chamran University of Ahvaz
2- Islamic Azad University, Shiraz
3- University of Yasouj
2- Islamic Azad University, Shiraz
3- University of Yasouj
Abstract: (133 Views)
Background & Aim: Exercise training, as a practical strategy, plays an important role in increasing adropin, adiponillin, reducing insulin resistance and preventing complications of overweight. Therefore, the present study aimed to determine the effect of exercise training on adropin, adiponillin, and insulin resistance indices in overweight and obese adult women.
Methods: A systematic search was conducted for English and Farsi articles published in PubMed, Web of Science, Scopus, Sid and Magiran databases until June 2024. The mean difference and 95% confidence interval (CI) were calculated using a random effects model. Heterogeneity was assessed using the I2 test, and publication bias was evaluated through visual analysis of the funnel plot and Egger's test.
Results: A total of 9 studies (10 interventions) and 208 overweight and obese adult female subjects were included in the meta-analysis. The results showed that exercise training had a non-significant effect on adropin [WMD=-0.387 (3.820 to -0.534) P=0.139], adipolin [WMD=3.320 (14.674 to -8.034) P=0.573], as well as a non-significant decrease in glucose [WMD=-7.222 (-2.153 to -12.291) P=0.005], insulin [WMD=-1.337 (0.503 to -3.178) P=0.154] and insulin resistance [WMD=0.254 (0.048 to -0.181) P=-0.067] compared to the control group of overweight and obese adult women.
Conclusion: Our meta-analysis revealed that exercise training did not significantly improve adropin, adiponillin, and insulin resistance indices in overweight and obese adult women. Specifically, exercise training did not lead to a significant decrease in these indices compared to the control group.
Methods: A systematic search was conducted for English and Farsi articles published in PubMed, Web of Science, Scopus, Sid and Magiran databases until June 2024. The mean difference and 95% confidence interval (CI) were calculated using a random effects model. Heterogeneity was assessed using the I2 test, and publication bias was evaluated through visual analysis of the funnel plot and Egger's test.
Results: A total of 9 studies (10 interventions) and 208 overweight and obese adult female subjects were included in the meta-analysis. The results showed that exercise training had a non-significant effect on adropin [WMD=-0.387 (3.820 to -0.534) P=0.139], adipolin [WMD=3.320 (14.674 to -8.034) P=0.573], as well as a non-significant decrease in glucose [WMD=-7.222 (-2.153 to -12.291) P=0.005], insulin [WMD=-1.337 (0.503 to -3.178) P=0.154] and insulin resistance [WMD=0.254 (0.048 to -0.181) P=-0.067] compared to the control group of overweight and obese adult women.
Conclusion: Our meta-analysis revealed that exercise training did not significantly improve adropin, adiponillin, and insulin resistance indices in overweight and obese adult women. Specifically, exercise training did not lead to a significant decrease in these indices compared to the control group.
Type of Study: Research |
Subject:
Special
Received: 2024/08/29 | Accepted: 2024/12/14 | Published: 2025/01/5
Received: 2024/08/29 | Accepted: 2024/12/14 | Published: 2025/01/5
References
1. Aydin S. Three new players in energy regulation: preptin, adropin and irisin. Peptides. 2014;56:94-110. [DOI:10.1016/j.peptides.2014.03.021]
2. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444(7121):875-80. [DOI:10.1038/nature05487]
3. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85-97. [DOI:10.1038/nri2921]
4. Linder K, Springer F, Machann J, Schick F, Fritsche A, Häring HU, et al. Relationships of body composition and liver fat content with insulin resistance in obesity-matched adolescents and adults. Obesity (Silver Spring). 2014;22(5):1325-31. [DOI:10.1002/oby.20685]
5. Rexrode KM, Buring JE, Manson JE. Abdominal and total adiposity and risk of coronary heart disease in men. Int J Obes Relat Metab Disord. 2001;25(7):1047-56. [DOI:10.1038/sj.ijo.0801615]
6. Sanchez-Margalet V, Valle M, Ruz FJ, Gascon F, Mateo J, Goberna R. Elevated plasma total homocysteine levels in hyperinsulinemic obese subjects. J Nutr Biochem. 2002;13(2):75-9. [DOI:10.1016/S0955-2863(01)00197-8]
7. Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation. 2006;113(22):2642-50. [DOI:10.1161/CIRCULATIONAHA.105.584060]
8. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008;8(6):468-81. [DOI:10.1016/j.cmet.2008.10.011]
9. Gao S, McMillan RP, Jacas J, Zhu Q, Li X, Kumar GK, et al. Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin. Diabetes. 2014;63(10):3242-52. [DOI:10.2337/db14-0388]
10. Shiroyeh A, Emami F, Sanaee M, Tarighi R. The Effect of Aerobic Training on Preptin, Adropin and Insulin Resistance in Overweight Men. Journal of Ardabil University of Medical Sciences. 2021;20(4):551-61. [DOI:10.52547/jarums.20.4.551]
11. Aydin S, Kuloglu T, Aydin S, Eren MN, Yilmaz M, Kalayci M, et al. Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes. Mol Cell Biochem. 2013;380(1-2):73-81. [DOI:10.1007/s11010-013-1660-4]
12. Buchanan CM, Phillips AR, Cooper GJ. Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion. Biochem J. 2001;360(Pt 2):431-9. [DOI:10.1042/bj3600431]
13. Butler AA, Tam CS, Stanhope KL, Wolfe BM, Ali MR, O'Keeffe M, et al. Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans. J Clin Endocrinol Metab. 2012;97(10):3783-91. [DOI:10.1210/jc.2012-2194]
14. Akcılar R, Emel Koçak F, Şimşek H, Akcılar A, Bayat Z, Ece E, Kökdaşgil H. The effect of adropin on lipid and glucose metabolism in rats with hyperlipidemia. Iran J Basic Med Sci. 2016;19(3):245-51.
15. Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, et al. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. J Biol Chem. 2011;286(40):34552-8. [DOI:10.1074/jbc.M111.277319]
16. Wei Z, Lei X, Seldin MM, Wong GW. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem. 2012;287(43):35804-14. [DOI:10.1074/jbc.M112.365965]
17. Tan BK, Lewandowski KC, O'Hare JP, Randeva HS. Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects. J Endocrinol. 2014;221(1):111-9. [DOI:10.1530/JOE-13-0537]
18. Takikawa T, Ohashi K, Ogawa H, Otaka N, Kawanishi H, Fang L, et al. Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction. PLoS One. 2020;15(12):e0243483. [DOI:10.1371/journal.pone.0243483]
19. Afroundeh R, bahram ME. The effect of resistance training with body weight (TRX) on serum levels of Perpetin, Adropine and metabolic factors associated with metabolic syndrome in overweight elderly men. Feyz Medical Sciences Journal. 2022;26(3):292-301.
20. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C, White RD. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29(6):1433-8. [DOI:10.2337/dc06-9910]
21. Soori R, Ramezankhani A, Ravasi AA, Akbarnejad A. Effect of Aerobic Exercise and Caloric Restriction on Serum Adropin Levels and HOMA-IR in Obese Sedentary Women. Sport Physiology. 2017;9(34):49-62.
22. Zafarmand O, Mogharnasi M, Moghadasi M. The effect of exercise training on serum levels of adipokines related to energy homeostasis (adropin, asprosin) and insulin resistance in patients with type 2 diabetes or obesity: A Systematic review and meta-Analysis. Journal of Applied Health Studies in Sport Physiology. 2024:-.
23. Saiedinejad E, Taheri Kalani A, Fatahi F. The effects of concurrent training and calorie restriction on anti-inflammatory adipokines and insulin sensitivity in obese women with fatty liver. Daneshvar Medicine. 2023;31(2):56-67.
24. Rezaeian N, Ravasi Aa, Soori R, Akbarnezhad A, Mirshafiey SA, Towfighi F. Effect of Resistance Training on Serum Levels of Adipolin and Insulin Resistance in Obese Women. Journal of Sport Biosciences. 2020;12(1):1-16.
25. Omidi M, Vismoradi P. Comparison of High and Moderate Intensity Aerobic Exercise on Serum Adipulin Levels and Some Indicators of Metabolic Syndrome in Obese Women. Iranian Journal of Diabetes and Lipid Disorders. 2022;21(6):404-13.
26. zafarmand o, Mogharnasi M, moghadasi m. The effect of exercise training on serum levels of adipokines related to energy homeostasis (adropin, asprosin) and insulin resistance in patients with type 2 diabetes or obesity: A Systematic review and meta-Analysis. Journal of Applied Health Studies in Sport Physiology. 2024;11(2):23-43.
27. Zafarmand O, Mogharnasi M. Effect Of High Intensity Interval Training (HIIT) On Resistin, Chemrin And Omentin-1: a systematic review article. Journal of Sports and Biomotor Sciences. 2024;16(31):119-32.
28. Kazeminasab F, Baharlooie M, Khalafi M. The Impact of Exercise on Serum Levels of Leptin and Adiponectin in Obese Children and Adolescents: A Systematic Review and Meta-Analysis. Iranian Journal of Endocrinology and Metabolism. 2022;23(6):409-25.
29. Khalafi M, Sakhaei MH, Kazeminasab F, Symonds ME, Rosenkranz SK. The impact of high-intensity interval training on vascular function in adults: A systematic review and meta-analysis. Frontiers in Cardiovascular Medicine. 2022;9:1046560. [DOI:10.3389/fcvm.2022.1046560]
30. Wen H, Wang L. Reducing effect of aerobic exercise on blood pressure of essential hypertensive patients: A meta-analysis. Medicine. 2017;96(11). [DOI:10.1097/MD.0000000000006150]
31. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629-34. [DOI:10.1136/bmj.315.7109.629]
32. Faramarzi E, Nazarali P. Comparison of Pilates and CXworx exercises on Adipolin Level and Insulin Resistance in Overweight Women. Journal of Ardabil University of Medical Sciences. 2022;22(3):239-49. [DOI:10.52547/jarums.22.3.239]
33. Azamian Jazi A, Moradi Sarteshnizi E, Fathi M, Azamian Jazi Z. Elastic band resistance training increases adropin and ameliorates some cardiometabolic risk factors in elderly women: A quasi-experimental study. BMC Sports Sci Med Rehabil. 2022;14(1):178. [DOI:10.1186/s13102-022-00571-6]
34. Galdavi R, Mogharnasi M, Nayebifar S. The effect of continuous training on plasma levels of adipolin, insulin sensitivity and body fat percent in overweight and obese women. Journal of Practical Studies of Biosciences in Sport. 2022;10(21):42-52.
35. Sharabiani S, Rajabi H, Motamedi P, Dehkhoda M, Kaviani M. The Effect of 8 Weeks of Combined Training on Serum Adropin and Nitric Oxide in Hypertensive Postmenopausal Women. Sport Physiology & Management Investigations. 2019;11(1):129-43.
36. Ramezankhani A, Soori R, Ravasi A, Akbarnejad A. An Investigation of the Effects of Long-Term Exercise on Serum Adropin Levels and Improvement of HOMA-IR in Obese Sedentary Women. Journal of Sport Biosciences. 2019;11(3):239-51.
37. Alizadeh R, Golestani N, Moradi L, Rezaeinejad N. Effect of Aerobic Exercise with Maximal Fat Oxidation Intensity, on Adropin and Insulin Resistance among Overweight Women. Iranian Journal of Endocrinology and Metabolism. 2018;20(2):81-8.
38. Rezaeian N RAA, Soori R, Akbatnezhad A, Mir shafiey S, Abbas Towfighi Zavare F. Effect of One Session of Aerobic Training on Serum Levels of Adipolin and Some Inflammatory Factors in Postmenopausal Women. Sport Physiology. 2017;8(32):49-66.
39. Rezaeian N, Ravasi AA, Soori R, Akbatnezhad A, Mir shafiey SA, Towfighi Zavare F. Effect of One Session of Aerobic Training on Serum Levels of Adipolin and Some Inflammatory Factors in Postmenopausal Women. Sport Physiology. 2016;8(32):49-66.
40. Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, et al. Adropin is a novel regulator of endothelial function. Circulation. 2010;122(11 Suppl):S185-92. [DOI:10.1161/CIRCULATIONAHA.109.931782]
41. Thapa D, Stoner MW, Zhang M, Xie B, Manning JR, Guimaraes D, et al. Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway. Redox Biol. 2018;18:25-32. [DOI:10.1016/j.redox.2018.06.003]
42. Gao S, McMillan RP, Zhu Q, Lopaschuk GD, Hulver MW, Butler AA. Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance. Mol Metab. 2015;4(4):310-24. [DOI:10.1016/j.molmet.2015.01.005]
43. Mehrdadi P, Kolahdouz Mohammadi R, Alipoor E, Eshraghian MR, Esteghamati A, Hosseinzadeh-Attar MJ. The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin/CTRP12 in Overweight and Obese Patients with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2017;125(3):156-62. [DOI:10.1055/s-0042-110570]
44. O'Gorman DJ, Karlsson HK, McQuaid S, Yousif O, Rahman Y, Gasparro D, et al. Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia. 2006;49(12):2983-92. [DOI:10.1007/s00125-006-0457-3]
45. Suh SH, Paik IY, Jacobs K. Regulation of blood glucose homeostasis during prolonged exercise. Mol Cells. 2007;23(3):272-9. [DOI:10.1016/S1016-8478(23)10717-5]
46. Sayın O, Tokgöz Y, Arslan N. Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease. J Pediatr Endocrinol Metab. 2014;27(5-6):479-84. [DOI:10.1515/jpem-2013-0296]
47. Henriksen EJ. Invited review: Effects of acute exercise and exercise training on insulin resistance. Journal of applied physiology. 2002;93 2:788-96. [DOI:10.1152/japplphysiol.01219.2001]
48. Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci. 2006;4(1):19-27. [DOI:10.7150/ijms.4.19]
49. Ganesh Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, et al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity (Silver Spring). 2012;20(7):1394-402. [DOI:10.1038/oby.2012.31]
50. Choi HN, Yim JE. Plasma Adropin as a Potential Marker Predicting Obesity and Obesity-associated Cancer in Korean Patients With Type 2 Diabetes Mellitus. J Cancer Prev. 2018;23(4):191-6. [DOI:10.15430/JCP.2018.23.4.191]
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