Volume 12, Issue 3 (12-2024)                   jmsthums 2024, 12(3): 65-77 | Back to browse issues page

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Y P, H S S, E R. The Impact of TRX Exercises and Avodin Supplementation on Liver Enzyme levels in Patients with Rheumatoid Arthritis. jmsthums 2024; 12 (3) :65-77
URL: http://jms.thums.ac.ir/article-1-1336-en.html
1- Shiraz Zand Institute of Higher Education
Abstract:   (140 Views)
Background & Aim: The increasing development of rheumatoid arthritis (RA) has led to the occurrence of other co-morbidities, including liver diseases. This research aimed to investigate the effect of TRX exercises with avodin supplementation on liver enzymes in patients with rheumatoid arthritis.
Methods: The present study was an applied type of research, using a semi-experimental method. The statistical population consist of patients with rheumatoid arthritis, from which 40 patients were selected using a convenient sampling method. These patients were then divided into four groups (N=10): 1) exercise, 2) supplement, 3) exercise + supplement, and 4) control. Blood samples were taken from all subjects at the beginning and end of the study to measure serum levels of AST, ALT, ALP, ALB, and TP. The subjects then underwent a course of TRX exercises and avodin supplementation (3 sessions per week, for 8 weeks, with adosage of 300 mg/kg body weight). Data analysis was done by the ANOVA, Bonferroni's post hoc test, t-test with using SPSS version 27 software with a significance level of P<0.05.
Results: The study showed a significant decrease in weight for the exercise-supplement group compared to both the control group (P=0.037) and the supplement group (P=0.021). Additionally, there was a significant decrease in liver enzymes AST, ALT, TP, and ALB in the exercise+supplement group compared to the control and supplement groups (P=0.001). Furthermore, there was a significant reduction in liver markers from pre-test to post-test in the exercise+supplement group (P=0.001).
Conclusion: Taking avodin while performing TRX exercises can effectively control weight and improve liver indicators. This combination of interventions may also help prevent the development of liver diseases in individuals with RA.
Full-Text [PDF 349 kb]   (122 Downloads)    
Type of Study: Research | Subject: Special
Received: 2024/09/1 | Accepted: 2024/11/30 | Published: 2025/01/5

References
1. Coates AM, Berard JA, King TJ, Burr JF. Physiological Determinants of Ultramarathon Trail-Running Performance. International Journal of Sports Physiology and Performance. 2021;1(aop):1-8. [DOI:10.31236/osf.io/y2kdx]
2. Nanke Y, Kotake S, Akama H, Kamatani N. Alkaline phosphatase in rheumatoid arthritis patients: possible contribution of bone-type ALP to the raised activities of ALP in rheumatoid arthritis patients. Clinical rheumatology. 2002;21(3):198-202. [DOI:10.1007/s10067-002-8285-4]
3. Kendall M, Cockel R, Becker J, Hawkins C. Rheumatoid liver? British Medical Journal. 1970;3(5716):221. [DOI:10.1136/bmj.3.5716.221-a]
4. Olago-Rakuomi AA. Prevalence of abnormal liver function tests in rheumatoid arthritis: University of Nairobi; 2017.
5. Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut. 2011;60(9):1278-83. [DOI:10.1136/gut.2011.242073]
6. Mohamed TS. EFFECT OF TRX SUSPENSION TRAINING AS A PREVENTION PROGRAM TO AVOID THE SHOULDER PAIN FOR SWIMMERS. Ovidius University Annals, Series Physical Education & Sport/Science, Movement & Health. 2016;16(2).
7. Asar S, Gandomi F, Mozafari M, Sohaili F. The effect of TRX vs. Aquatic exercises on self-reported knee instability and affected factors in women with knee osteoarthritis: a randomized controlled trial. 2020. [DOI:10.21203/rs.2.13552/v4]
8. Co ASSP. Avodin ,https://ariansalamat.com/en/product/capsule-avodin/#tab additional_information 2021
9. Hejazi K, Hackett D. Effect of Exercise on Liver Function and Insulin Resistance Markers in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Medicine. 2023;12(8):3011. [DOI:10.3390/jcm12083011]
10. Sherizade H, Rahimi M, Banitalebi E. The effect of TRX suspension resistance training on liver enzymes in obese women. EBNESINA. 2022;24(4):31-42.
11. Li J, Wang F, Chen K, Xia Y, Lu J, Zhou Y, et al. Effects of physical activity on liver function in patients with non-alcoholic fatty liver disease: A meta-analysis. So J Immunol. 2015;3:1-6. [DOI:10.15226/2372-0948/3/5/00143]
12. Wang S-t, Zheng J, Peng H-w, Cai X-l, Pan X-t, Li H-q, et al. Physical activity intervention for non-diabetic patients with non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials. BMC gastroenterology. 2020;20:1-12. [DOI:10.1186/s12876-020-01204-3]
13. Smart N, King N, McFarlane J, Graham P, Dieberg G. Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis. British journal of sports medicine. 2018;52(13):834-43. [DOI:10.1136/bjsports-2016-096197]
14. Freer CL, George ES, Tan S-Y, Abbott G, Dunstan DW, Daly RM. Effect of progressive resistance training with weight loss compared with weight loss alone on the fatty liver index in older adults with type 2 diabetes: secondary analysis of a 12-month randomized controlled trial. BMJ Open Diabetes Research and Care. 2022;10(5):e002950. [DOI:10.1136/bmjdrc-2022-002950]
15. Stevanović J, Beleza J, Coxito P, Ascensão A, Magalhães J. Physical exercise and liver "fitness": Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease. Molecular metabolism. 2020;32:1-14. [DOI:10.1016/j.molmet.2019.11.015]
16. Koutoukidis DA, Koshiaris C, Henry JA, Noreik M, Morris E, Manoharan I, et al. The effect of the magnitude of weight loss on non-alcoholic fatty liver disease: a systematic review and meta-analysis. Metabolism. 2021;115:154455. [DOI:10.1016/j.metabol.2020.154455]
17. Babu AF, Csader S, Lok J, Gomez-Gallego C, Hanhineva K, El-Nezami H, et al. Positive effects of exercise intervention without weight loss and dietary changes in NAFLD-related clinical parameters: a systematic review and meta-analysis. Nutrients. 2021;13(9):3135. [DOI:10.3390/nu13093135]
18. Park SH, Kim DJ, Plank LD. Association of grip strength with non-alcoholic fatty liver disease: investigation of the roles of insulin resistance and inflammation as mediators. European journal of clinical nutrition. 2020;74(10):1401-9. [DOI:10.1038/s41430-020-0591-x]
19. Dolati M, Ghazalian F, Abednatanzi H. The effect of a period of TRX training on lipid profile and body composition in overweight women. International Journal of Sports Science. 2017;7(3):151-8.
20. Smith LE, Snow J, Fargo JS, Buchanan CA, Dalleck LC. The acute and chronic health benefits of TRX Suspension Training® in healthy adults. Int J Res Ex Phys. 2016;11(2):1-15.
21. Ghorbanian B, Saberi Y, Babaloyan S. The effect of eight weeks of high-intensity interval training on changes in atherogenic parameters and liver enzymes in patients with non-alcoholic fatty liver. EBNESINA. 2021;23(3):23-32.
22. Fernandes L, Sullivan S, McFarlane I, Wojcicka B, Warnes T, Eddleston A, et al. Studies on the frequency and pathogenesis of liver involvement in rheumatoid arthritis. Annals of the Rheumatic Diseases. 1979;38(6):501-6. [DOI:10.1136/ard.38.6.501]

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