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Kheiry M, Shafiei E, Mamizadeh M, Maleki F. Therapeutic effects of ethanolic and aqueous leaf and branch extracts from Calotropis procera on common warts. jmsthums 2025; 13 (1) :1-11
URL: http://jms.thums.ac.ir/article-1-1382-en.html
URL: http://jms.thums.ac.ir/article-1-1382-en.html
1- Non-communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran
2- Psychosocial Trauma Research Center, Ilam University of Medical Sciences, Ilam, Iran
3- Department of Dermatology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
4- Clinical Research Development Unit, Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran
2- Psychosocial Trauma Research Center, Ilam University of Medical Sciences, Ilam, Iran
3- Department of Dermatology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
4- Clinical Research Development Unit, Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran
Abstract: (932 Views)
Background & Aim: Cutaneous warts are non-malignant proliferative skin lesions and can occur at any age. Current treatments for plantar warts are costly and relatively ineffective. This study was designed to assess the therapeutic efficacy of ethanolic and aqueous extracts of Calotropis procera leaves and branches in the treatment of common warts.
Methods: This study included patients who visited a dermatology specialist to have their foot warts removed and who had at least three warts on their foot. Aqueous extract treatment was applied to the first wart for each subject, ethanol extract for the second wart, and conventional salicylic acid therapy for the third wart (which was the reference treatment). All treatments were administered for one month, using a single drop of each respective treatment applied daily to the designated warts separately. Statistical analysis was performed using repeated measures ANOVA for comparison between groups. Data analysis was performed using SPSS software version 26, and the level of significance was set at 5%.
Results: This is an experimental study involving 41 participants (19 males and 22 females). Statistical analysis revealed a significant difference between treatment methods at the 5% error level (F = 12.416, P < 0.05). The ethanolic extract from Calotropis procera showed the highest reduction in the mean diameter of the wart compared to other treatment approaches. Additionally, no significant interactions were detected between treatment type and age (F = 0.634, P > 0.05) or gender (F = 0.431, P > 0.05) of the patients.
Conclusion: The ethanolic extract of Calotropis procera represents a promising therapeutic approach for plantar warts, with minimal adverse effects, for clinicians to consider.
Methods: This study included patients who visited a dermatology specialist to have their foot warts removed and who had at least three warts on their foot. Aqueous extract treatment was applied to the first wart for each subject, ethanol extract for the second wart, and conventional salicylic acid therapy for the third wart (which was the reference treatment). All treatments were administered for one month, using a single drop of each respective treatment applied daily to the designated warts separately. Statistical analysis was performed using repeated measures ANOVA for comparison between groups. Data analysis was performed using SPSS software version 26, and the level of significance was set at 5%.
Results: This is an experimental study involving 41 participants (19 males and 22 females). Statistical analysis revealed a significant difference between treatment methods at the 5% error level (F = 12.416, P < 0.05). The ethanolic extract from Calotropis procera showed the highest reduction in the mean diameter of the wart compared to other treatment approaches. Additionally, no significant interactions were detected between treatment type and age (F = 0.634, P > 0.05) or gender (F = 0.431, P > 0.05) of the patients.
Conclusion: The ethanolic extract of Calotropis procera represents a promising therapeutic approach for plantar warts, with minimal adverse effects, for clinicians to consider.
Type of Study: Applicable |
Subject:
Special
Received: 2024/08/23 | Accepted: 2025/02/18 | Published: 2025/03/21
Received: 2024/08/23 | Accepted: 2025/02/18 | Published: 2025/03/21
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