Volume 5, Issue 4 (3-2018)
jmsthums 2018, 5(4): 60-71 |
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GHolami M, Sadegh M. Assessing the effect of drug tolerance due to chronic administration of morphine and salicylate on synaptic plasticity. jmsthums 2018; 5 (4) :60-71
URL: http://jms.thums.ac.ir/article-1-471-en.html
URL: http://jms.thums.ac.ir/article-1-471-en.html
1- Neurosciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
2- Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
2- Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Abstract: (6634 Views)
Background & Aim: Salicylates and opioids are widely used in chronic pain relief. Chronic use of these drugs reorganizes synaptic function, especially experience-dependent plasticity in brain regions. Therefore, in this study the effects of chronic administration of salicylate and morphine on synaptic plasticity were investigated.
Methods: in this review, Elsevier, Science Direct, PubMed and Google Scholar databases were searched for the following keywords: salicylate, morphine, drug tolerance, and synaptic plasticity. At the end, 62 of the obtained reports were included in the study.
Results: In addition to induction of tolerance to anti-nociceptive effect and cross-tolerance, chronic salicylate administration as like as morphine has long-lasting effects on hippocampal neuronal networks which are manifested as excitability of neurons and ability of activity and experience-dependent plasticity. Some of these effects can be documented in the hippocampus-related functions such as spatial learning and memory.
Conclusion: Considering the effects of salicylate and morphine on the nervous system and synaptic transmission, the effects of these drugs on the processing of input data and as a result on cognitive functioning would not be unlikely, thus necessitating further behavioral and electrophysiological studies.
Methods: in this review, Elsevier, Science Direct, PubMed and Google Scholar databases were searched for the following keywords: salicylate, morphine, drug tolerance, and synaptic plasticity. At the end, 62 of the obtained reports were included in the study.
Results: In addition to induction of tolerance to anti-nociceptive effect and cross-tolerance, chronic salicylate administration as like as morphine has long-lasting effects on hippocampal neuronal networks which are manifested as excitability of neurons and ability of activity and experience-dependent plasticity. Some of these effects can be documented in the hippocampus-related functions such as spatial learning and memory.
Conclusion: Considering the effects of salicylate and morphine on the nervous system and synaptic transmission, the effects of these drugs on the processing of input data and as a result on cognitive functioning would not be unlikely, thus necessitating further behavioral and electrophysiological studies.
Type of Study: Applicable |
Subject:
Special
Received: 2018/01/13 | Accepted: 2018/04/12 | Published: 2018/04/12
Received: 2018/01/13 | Accepted: 2018/04/12 | Published: 2018/04/12
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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