Volume 12, Issue 3 (12-2024)
jmsthums 2024, 12(3): 27-39 |
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R R, J S. Studing the effect of hydroalcoholic extract of Avicennia marina leaves on antioxidant and renal indices in alloxan-induced diabetic rats. jmsthums 2024; 12 (3) :27-39
URL: http://jms.thums.ac.ir/article-1-1332-en.html
URL: http://jms.thums.ac.ir/article-1-1332-en.html
1- Payame Noor University Tehran
Abstract: (119 Views)
Background & Aim: Diabetic nephropathy is a side effect of oxidative stress caused by the production of free radicals during hyperglycemia in individuals with type 1 diabetes. The purpose of this study was to investigate the impact of a hydroalcoholic extract of Avicennia marina leaves on antioxidant levels and renal function in diabetic rats treated with alloxan.
Methods: In this study, 32 adult male Wistar rats were randomly divided into four equal groups: a control group, a diabetic control group, and two diabetic groups treated with hydroalcoholic extract of Avicennia marina leaves at concentrations of 50 and 100 mg/kg. The experimental diabetes model was induced in the diabetic control group and the treated diabetic groups through a single intraperitoneal injection of alloxan monohydrate. At the end of the treatment period, we assessed the activity of antioxidant enzymes and renal indices of kidney tissue.
Results: The results of this study revealed a significant increase in the activity of superoxide dismutase, glutathione peroxidase, and catalase enzymes, along with a significant decrease in malondialdehyde in the diabetic groups that received doses of 50 and 100 mg/kg compared to the diabetic control group (P<0.05). Additionally, biochemical evaluations indicated a significant decrease in blood urea, blood urea nitrogen, uric acid, and creatinine, as well as a significant increase in albumin (P<0.05).
Conclusion: The Avicennia marina plant reduced hyperglycemia caused by diabetes, and brought the levels of free radicals and the body's innate antioxidant defense system closer to balance.
Methods: In this study, 32 adult male Wistar rats were randomly divided into four equal groups: a control group, a diabetic control group, and two diabetic groups treated with hydroalcoholic extract of Avicennia marina leaves at concentrations of 50 and 100 mg/kg. The experimental diabetes model was induced in the diabetic control group and the treated diabetic groups through a single intraperitoneal injection of alloxan monohydrate. At the end of the treatment period, we assessed the activity of antioxidant enzymes and renal indices of kidney tissue.
Results: The results of this study revealed a significant increase in the activity of superoxide dismutase, glutathione peroxidase, and catalase enzymes, along with a significant decrease in malondialdehyde in the diabetic groups that received doses of 50 and 100 mg/kg compared to the diabetic control group (P<0.05). Additionally, biochemical evaluations indicated a significant decrease in blood urea, blood urea nitrogen, uric acid, and creatinine, as well as a significant increase in albumin (P<0.05).
Conclusion: The Avicennia marina plant reduced hyperglycemia caused by diabetes, and brought the levels of free radicals and the body's innate antioxidant defense system closer to balance.
Type of Study: Research |
Subject:
Special
Received: 2024/08/27 | Accepted: 2024/12/4 | Published: 2025/01/5
Received: 2024/08/27 | Accepted: 2024/12/4 | Published: 2025/01/5
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